Isochorismatase domain-containing protein 1 (ISOC1)

Isochorismatase domain-containing protein 1 (ISOC1) is a conserved human protein that contains an isochorismatase domain, typically associated with hydrolase activity. While its detailed biochemical activity in humans is not fully resolved, ISOC1 is emerging as a modulator of cell metabolism, proliferation, cell cycle progression, and inflammation. Recent studies have identified ISOC1 as upregulated in several solid tumors, where it enhances cancer cell proliferation, migration, invasion, and survival by modulating key signaling pathways such as AKT/GSK-3β and DNA damage response networks. Knockdown or silencing of ISOC1 inhibits tumor cell growth and promotes apoptosis. ISOC1 further participates in inflammation-related signaling pathways and may influence immune cell function and infection response. Its complex, context-dependent roles make it a potential—but challenging—therapeutic target, as it may act as an oncogene or a tumor suppressor depending on tissue and cancer type[1][3][5].

Other names

ISOC1CGI-111Isochorismatase domain containing 1

Not explicitly characterized; reported mechanisms relate to modulation of signaling pathways such as AKT/GSK-3β, STAT1, and caspase/PARP-mediated apoptosis in preclinical models[5]. Possible mechanisms for future therapeutic targeting could include inhibition of ISOC1 to induce cancer cell apoptosis, slow tumor proliferation, and promote cell cycle arrest[3][5].