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Isoleucine--tRNA Ligase
- Molecular classification
- Enzyme, Aminoacyl-tRNA synthetase
01
Overview
Isoleucine--tRNA ligase (IleRS) is an enzyme responsible for attaching L-isoleucine to its cognate tRNA (tRNA^Ile). This aminoacylation reaction is crucial for accurate protein synthesis. IleRS employs a double-sieve mechanism to ensure fidelity, preventing misincorporation of similar amino acids like valine. It is a member of the class Ia aminoacyl-tRNA synthetases family and essential for cellular function across all life domains.
- Other names
- Isoleucyl-tRNA synthetaseIsoleucyl-transfer RNA synthetaseIsoleucine-tRNA synthetaseIsoleucine translase
02
Mechanism of action
Inhibition of isoleucine--tRNA ligase prevents the charging of tRNA^Ile with isoleucine, leading to disruption of protein synthesis.
03
Biological functions
Aminoacylation of tRNAProtein biosynthesisTranslation fidelity
04
Safety considerations
Potential for off-target effects due to structural similarities with other aminoacyl-tRNA synthetases.
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