Target intelligence / Profile preview

Isoleucyl-tRNA Synthetase (IleRS)

Target: IleRS
Molecular classification: Enzyme, Aminoacyl-tRNA Synthetase, Class I Aminoacyl-tRNA Synthetase

Overview

Isoleucyl-tRNA synthetase (IleRS) is an essential enzyme responsible for attaching isoleucine to its corresponding tRNA, ensuring accurate protein synthesis. It employs a double-sieve editing mechanism to prevent misincorporation of similar amino acids like valine. IleRS is a potential therapeutic target, especially in autoimmune diseases due to its association with autoantibodies.

Mechanism of action

Inhibition of isoleucine-tRNA charging, leading to disruption of protein synthesis

Biological functions

Aminoacylation of tRNAProtein synthesismRNA translationProofreadingQuality control of protein synthesis

Disease associations

Autoimmune diseases (potential target, based on autoantibody association)

Safety considerations

Potential for off-target effects due to structural similarity with other aminoacyl-tRNA synthetasesPossible disruption of mitochondrial function if mitochondrial isoforms are targeted

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