Isomaltulose

Isomaltulose is a naturally occurring disaccharide composed of glucose and fructose linked via an alpha-1,6-glycosidic bond [1]. It is a structural isomer of sucrose, but its unique linkage makes it significantly more resistant to enzymatic hydrolysis by the sucrase-isomaltase complex in the human small intestine [2]. Because it is digested and absorbed slowly and completely, it provides a low glycemic index and a reduced insulinemic response compared to traditional sugars [3]. This metabolic profile makes it useful in clinical nutrition for managing blood glucose levels in patients with type 2 diabetes and metabolic syndrome [1][3]. Furthermore, isomaltulose is non-cariogenic as it is not fermented by oral bacteria like Streptococcus mutans, thus preventing the production of enamel-eroding acids [2]. Although it is discussed in therapeutic contexts, it functions as a metabolic substrate rather than a classical pharmacological target like a receptor or enzyme [1].

Other names

Palatinose6-O-alpha-D-Glucopyranosyl-D-fructose6-O-alpha-D-glucopyranosyl-D-fructofuranoseIsomaltulose anhydrous

Acts as a slow-release carbohydrate source through slow enzymatic cleavage by the sucrase-isomaltase enzyme complex in the small intestine, leading to sustained glucose release and minimal insulin spikes.