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Target intelligence / Profile preview
Isopentenyl-diphosphate delta isomerase 2 (IDI2)
- Target
- IDI2
- Molecular classification
- Enzyme
01
Overview
Isopentenyl-diphosphate delta isomerase 2 (IDI2) is an enzyme that catalyzes the conversion of isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP), a key step in the biosynthesis of isoprenoids. This enzyme is involved in the superpathway of cholesterol biosynthesis and plays a role in metabolic pathways related to isoprenoid synthesis. IDI2 is localized to mitochondria and potentially plays distinct roles compared to its paralog, IDI1. Its involvement has been linked to several diseases, including neurodegenerative conditions and sporadic amyotrophic lateral sclerosis.
- Other names
- Isopentenyl pyrophosphate isomerase 2IPP isomerase 2Isopentenyl-diphosphate delta-isomerase 2IPPI2
02
Mechanism of action
This enzyme catalyzes the isomerization of isopentenyl diphosphate to dimethylallyl diphosphate, which is crucial for the synthesis of various isoprenoids.
03
Biological functions
Biosynthesis of isoprenoidsConversion of isopentenyl diphosphate to dimethylallyl diphosphateRole in cholesterol biosynthesis
04
Disease associations
Cancer (through implication in cholesterol biosynthesis)Neurodegenerative diseases (e.g., potential role in Lewy body disease)Sporadic amyotrophic lateral sclerosis
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