Target intelligence / Profile preview

Isthmin 1 (ISM1)

Target: ISM1
Molecular classification: Secreted protein, Thrombospondin domain-containing protein, Adhesion-associated domain-containing protein

Overview

Isthmin 1 (ISM1) is a secreted protein expressed in skin, mucosal tissues, and selected lymphocyte populations. It contains a thrombospondin domain and an adhesion-associated domain. ISM1 is involved in immune responses, particularly in Th17 cell polarization, and exhibits anti-angiogenic properties. It may mediate lymphocyte effector functions and participate in both innate and acquired immunity.

Mechanism of action

Unknown

Biological functions

Immune responseAnti-angiogenesisLymphocyte effector functionInnate immunityAcquired immunity

Disease associations

Wound healingInflammationCancer (angiogenesis related)

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