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Itaconate Pathway (None)
- Target
- None
- Molecular classification
- Metabolic pathway, Enzyme network
01
Overview
The itaconate pathway is a metabolic and immunoregulatory axis centered on the production and function of itaconate in immune cells, primarily activated macrophages. It links cellular metabolism with innate immunity, inflammation control, and host defense. Key functions include antimicrobial activity, immunomodulation, and metabolic reprogramming. It exerts its effects through mechanisms such as protein alkylation and enzyme inhibition, making it a potential therapeutic target for diseases involving excessive inflammation or dysregulated immunity.
- Other names
- Itaconic acid pathwayACOD1/IRG1 pathwayImmune-responsive gene 1 pathway
02
Mechanism of action
Inhibition of bacterial isocitrate lyase (ICL); Inhibition of succinate dehydrogenase (SDH); Covalent modification (alkylation) of cysteine residues on target proteins
03
Biological functions
Antimicrobial activityImmunomodulationMetabolic reprogrammingRegulation of inflammationOxidative stress regulation
04
Disease associations
InfectionInflammationAutoimmune diseasesCancer
05
Safety considerations
Off-target effects of itaconate derivativesPotential disruption of cellular metabolismUnknown long-term effects of pathway modulation
06
Interacting drugs
Dimethyl itaconate (DI)
1 more in the full profile.
07
Biomarkers
Itaconate levelsACOD1/IRG1 expression
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