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ITGA2 Antisense RNA 1 (ITGA2-AS1)

Target: ITGA2-AS1
Molecular classification: Long non-coding RNA (lncRNA), Antisense RNA, Other (regulatory RNA)

Overview

ITGA2 Antisense RNA 1 (ITGA2-AS1) is a long non-coding RNA gene transcribed antisense to the ITGA2 gene, with regulatory functions in gene expression modulation. ITGA2-AS1 acts as a tumor suppressor lncRNA, potentially downregulating the expression of the oncogenic integrin alpha-2 (ITGA2) by complementary base pairing to the 5′ and 3′-UTR regions of ITGA2 mRNA, interfering with mRNA stability and/or translation. Its main biological significance lies in its role in inhibiting cancer-related pathways associated with ITGA2, including cell proliferation, adhesion, migration, invasion, and epithelial-to-mesenchymal transition[1][2]. No drugs are known to target ITGA2-AS1 directly, and it is not considered a classical therapeutic target.

Other names: ITGA2-AS1I2ALRITGA2 Antisense LncRNA

Biological functions

Regulation of ITGA2 mRNA (gene expression regulation)Tumor suppressor gene function (downregulates oncogenic ITGA2)Possible involvement in cell adhesion, proliferation, invasion, migration through regulation of integrin pathways

Disease associations

Cancer (acts as a tumor suppressor against oncogenic ITGA2, which is implicated in cancer progression, adhesion, metastasis, etc.)

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