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ITGA6 antisense RNA 1 (ITGA6-AS1)
- Target
- ITGA6-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA, Other
01
Overview
ITGA6 antisense RNA 1 (ITGA6-AS1) is a long non-coding RNA transcribed antisense to the ITGA6 gene on chromosome 2. It has no protein-coding potential and is found in both the cytoplasm and nucleus of multiple myeloma (MM) cells[1]. ITGA6-AS1 forms an RNA duplex with the ITGA6 pre-mRNA, increasing its stability and, as a result, upregulating ITGA6 expression. Higher expression of ITGA6-AS1 is associated with reduced invasion of MM cells, likely through stabilizing ITGA6 RNA and attenuating metastatic potential. ITGA6-AS1 expression correlates positively with ITGA6 in MM samples, and overexpression of ITGA6-AS1 reduces MM cell invasion via this regulatory axis. Both ITGA6 and ITGA6-AS1 may be useful as prognostic biomarkers for multiple myeloma. No current therapeutics are known to directly target ITGA6-AS1, and it is not itself considered a therapeutic target such as a receptor or enzyme[1].
- Other names
- lncIHATAC078883.3lncRNA induced by hypoxia and abundant in TNBCPDK1-AS1ITGA6 antisense RNA 1PDK1 and ITGA6 antisense RNA 1
02
Biological functions
Regulation of gene expressionRegulation of RNA stabilityInhibition of cell invasionPost-transcriptional regulationOther
03
Disease associations
Cancermultiple myeloma (including progression to secondary plasma cell leukemia)Potential roles in triple-negative breast cancer (by alias/inference)Other
04
Biomarkers
May serve as a biomarker for prognosis and risk stratification in multiple myeloma
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