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Target intelligence / Profile preview
ITGA9 antisense RNA 1 (ITGA9-AS1)
- Target
- ITGA9-AS1
- Molecular classification
- Long non-coding RNA, Antisense RNA, Other (non-coding RNA)
01
Overview
ITGA9 antisense RNA 1 (ITGA9-AS1) is a long non-coding antisense RNA gene located near ITGA9, its sense partner. ITGA9-AS1 is most abundantly found in the cytoplasm of NSCLC cells where it acts by sponging miR-4765, thereby relieving repression of ITGA9 mRNA, and by recruiting RNA-binding protein HNRNPU, which stabilizes ITGA9 mRNA. Functionally, ITGA9-AS1 inhibits cell proliferation and promotes apoptosis in NSCLC models and is downregulated in NSCLC relative to normal tissue, indicating a tumor-suppressive role. It is being investigated as a potential biomarker or therapeutic strategy in cancer, particularly lung carcinoma.
- Other names
- ITGA9-AS1ITGA9 antisense RNA 1lncRNA ITGA9-AS1
02
Biological functions
Regulation of gene expression (positive regulation of ITGA9 mRNA)Competing endogenous RNA (ceRNA) activity (sponging miR-4765)Recruitment of RNA-binding protein HNRNPU to stabilize ITGA9 mRNASuppression of cell proliferation (in NSCLC cell lines)Promotion of apoptosis (in NSCLC cell lines)
03
Disease associations
Cancernon-small cell lung cancer
04
Biomarkers
Downregulation of ITGA9-AS1 in NSCLC tissue compared to normal may serve as a negative biomarker for NSCLCDownregulation associated with poor outcomes and tumor progression
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