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Izumo sperm-egg fusion protein 2 (IZUMO2)
- Target
- IZUMO2
- Molecular classification
- Other (testis-specific cell surface protein; single Ig domain-containing protein)
01
Overview
Izumo sperm-egg fusion protein 2 (IZUMO2) is a testis-specific, membrane-associated protein and a member of the IZUMO family, which also comprises critical sperm proteins like IZUMO1 required for mammalian fertilization[1][3]. While IZUMO1 is essential for sperm-egg adhesion and fusion, the precise function of IZUMO2 remains less defined, but it is expressed in testicular tissue and implicated in sperm-egg interaction pathways[1][3][5]. IZUMO2 is not currently recognized as a therapeutic target and no clinical drugs interact with it; its known role is limited to fertility biology rather than disease or therapy[1][5].
- Other names
- C19orf41SCRLUNQ6978/PRO21961MGC33947PLAL6978PRO21961
02
Biological functions
Sperm-egg adhesion, likely involved in fertilization (role less clearly defined than IZUMO1)
03
Disease associations
Other (not clearly associated with specific diseases)
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