Jade family PHD finger protein 2 (JADE2)

Jade family PHD finger protein 2 (JADE2) is an E3 ubiquitin-protein ligase and a chromatin-associated protein distinguished by plant homeodomain (PHD) zinc finger motifs. It participates in the regulation of chromatin structure by acting as a scaffold subunit of certain HBO1 histone acetyltransferase complexes, conferring acetylation activity to specific lysines on histone H4 and contributing to DNA replication and cell cycle regulation[3][5]. JADE2 also mediates ubiquitination and subsequent proteasomal degradation of selected substrates such as the histone demethylase KDM1A, suggesting it plays a role in protein quality control and epigenetic regulation[3][5]. Through these functions, JADE2 impacts DNA synthesis, chromatin remodeling, and potentially neurogenesis. While E3 ubiquitin ligases are considered therapeutic targets in cancer and other diseases, there are no approved drugs that directly target JADE2 to date, and its involvement in disease is based on pathway association and family homology rather than direct clinical evidence[2][3][5].

Other names

E3 ubiquitin-protein ligase Jade-2KIAA0239PHF15JADE-2PHD finger protein 15

Modulation of protein stability via polyubiquitination and proteasomal degradation (e.g., ubiquitination of histone demethylase KDM1A); Alteration of chromatin structure via histone acetylation as part of HBO1 complex