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Target intelligence / Profile preview
Jade family PHD finger protein 3 (JADE3)
- Target
- JADE3
- Molecular classification
- PHD finger protein (plant homeodomain zinc finger protein), Epigenetic regulatory protein, Histone modification scaffold protein, Chromatin remodeling associated protein
01
Overview
Jade family PHD finger protein 3 (JADE3, also known as PHF16, KIAA0215, and PHD finger protein 16) is a nuclear protein characterized by tandem PHD (plant homeodomain) finger motifs that function in chromatin recognition and regulation[1][3][4]. As a member of the JADE protein family (JADE1, JADE2, JADE3), it acts as a core subunit and scaffold for some HBO1 (histone acetyltransferase binding to ORC1) complexes that mediate histone H4 acetylation, thereby influencing chromatin structure, gene expression, and transcriptional activation[1][3][4]. JADE family proteins are implicated in key biological processes including gene regulation, chromatin remodeling, and cellular differentiation. Although the detailed function of JADE3 specifically remains less well characterized than JADE1, it is considered a protein coding gene essential for chromatin modification and gene regulation. Dysregulation or mutation of JADE family members is linked to certain diseases, most notably cancer, underscoring their importance in maintaining genomic stability and cellular identity[1][3][4].
- Other names
- Protein Jade-3JADE3KIAA0215PHF16Jade family PHD finger protein 3PHD finger protein 16JADE-3
02
Mechanism of action
Not applicable (No drugs specifically target JADE3 as a primary mechanism at present).
03
Biological functions
Histone acetylation (specifically histone H4 acetylation in chromatin context)Transcriptional regulationChromatin remodelingRegulation of gene expressionPotential involvement in cell cycle and cellular differentiation (by analogy to other JADE family members)
04
Disease associations
Cancer (implicated through association with chromatin modification and regulation; overexpression or mutations have been noted in related JADE family members and may be relevant for JADE3 as well)Potentially developmental and neurological disorders, based on general family characteristics, but specific evidence for JADE3 is limited
05
Safety considerations
No direct safety concerns or therapeutic challenges reported for JADE3 as a target. Given its role in basic chromatin regulation, targeting could theoretically risk broad effects on gene expression, but this is speculative.
06
Biomarkers
No specific established biomarkers for JADE3 in therapeutic monitoring or patient selection at this time. Altered expression could potentially be explored as a biomarker in cancer or differentiation contexts, by analogy to other chromatin regulators.
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