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Target intelligence / Profile preview
Jagged Canonical Notch Ligand 1 (JAG1)
- Target
- JAG1
- Molecular classification
- Cell surface ligand, Receptor ligand
01
Overview
Jagged1 is a cell surface ligand that plays a crucial role in the Notch signaling pathway. It is involved in cell fate determination, development, and tissue homeostasis. Aberrant expression or mutations in JAG1 are associated with diseases like Alagille syndrome and various cancers. The protein is composed of extracellular EGF-like repeats, a DSL domain, and a cysteine-rich region, and its interaction with Notch receptors initiates a cascade of signaling events that affect gene transcription.
- Other names
- Jagged-1CD339 antigenAlagille syndrome 1 proteinHJ1
02
Mechanism of action
Notch signaling pathway modulation
03
Biological functions
Signal transductionCell differentiationCell proliferationAngiogenesisNeurogenesisImmune system modulation
04
Disease associations
CancerCardiovascular diseaseCongenital heart diseaseAlagille syndrome
05
Safety considerations
Potential for dysregulation in cancer and developmental disorders
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