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Target intelligence / Profile preview
Tyrosine-protein kinase JAK2 (JAK2)
- Target
- JAK2
- Molecular classification
- Protein kinase superfamily, Janus kinase family, Enzyme, Non-receptor tyrosine kinase
01
Overview
Tyrosine-protein kinase JAK2 is a non-receptor tyrosine kinase that plays a crucial role in cell growth, development, differentiation, and histone modifications. It is a central component of the JAK/STAT signaling pathway, mediating signals from cytokine receptors to regulate gene expression. Dysregulation of JAK2 is implicated in various myeloproliferative disorders.
- Other names
- Janus kinase 2JTK10THCYT3JAK-2
02
Mechanism of action
JAK2 inhibitors block the kinase activity of JAK2, thereby inhibiting the JAK/STAT signaling pathway.
03
Biological functions
Signal transductionCell growthCell developmentCell differentiationHistone modificationInnate immunityAdaptive immunityGene expression regulation
04
Disease associations
Myeloproliferative disordersPolycythemia veraEssential thrombocythemia
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