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Janus kinase and microtubule-interacting protein 2 (JAKMIP2)
- Target
- JAKMIP2
- Molecular classification
- Other (Golgi matrix protein, structural scaffold), not classically a receptor, enzyme, transporter, ion channel, or transcription factor
01
Overview
Janus kinase and microtubule-interacting protein 2 (JAKMIP2) is a protein-coding gene product primarily associated with the Golgi matrix. It is implicated in the negative regulation of secretory cargo transit and serves as a structural scaffold of the Golgi apparatus. The protein interacts with microtubules and kinases but is not itself a kinase, microtubule, or classical drug target. Alternative splicing results in multiple transcript variants. Diseases associated with JAKMIP2 include microcystic adenoma, and it has been identified as a tumor antigen in certain lymphomas. It is part of a family containing at least one paralog, JAKMIP1.
- Other names
- JAMIP2KIAA0555NECC1CTCL tumor antigen HD-CL-04Neuroendocrine long coiled-coil protein 1Jak and microtubule interacting protein 2
02
Biological functions
Microtubule bindingKinase bindingRegulation of secretory cargo transitGolgi organization/structural scaffold
03
Disease associations
Microcystic adenomapossible roles as CTCL (cutaneous T-cell lymphoma) tumor antigen
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