Target intelligence / Profile preview

Janus Kinase Pseudokinase Domain (JH2)

Target: JH2
Molecular classification: Protein Domain, Pseudokinase, Regulatory Domain

Overview

The Janus kinase pseudokinase domain (JH2) is a regulatory domain found in all members of the Janus kinase (JAK) family. The JH2 domain is located adjacent to the canonical tyrosine kinase domain (JH1) at the C-terminus of these proteins. It primarily functions as a negative regulator of the associated tyrosine kinase activity by direct interaction with the JH1 domain. Mutations in JH2 are implicated in hematological malignancies and other cancers, making it a potential therapeutic target.

Other names: JAK Pseudokinase DomainJH2 Domain

Mechanism of action

Inhibition of JH2/JH1 interface, Modulation of ATP binding

Biological functions

Negative regulation of kinase activityAutoinhibitionModulation of kinase activity

Disease associations

CancerMyeloproliferative Neoplasms (MPNs)

Safety considerations

Potential for off-target effectsResistance mechanisms

Beyond the preview

Go deeper on Janus Kinase Pseudokinase Domain (JH2).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Janus Kinase Pseudokinase Domain (JH2).

Explore the full profile