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Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) Pathway (JAK-STAT Pathway)
- Target
- JAK-STAT Pathway
- Molecular classification
- Signaling pathway, Transcription factor, Kinase signaling pathway
01
Overview
The JAK-STAT pathway is an intracellular signaling cascade that transmits information from extracellular signals to the nucleus, regulating gene expression. It involves JAK kinases, STAT transcription factors, and cell-surface receptors. Dysregulation is implicated in autoimmune disorders, hematologic malignancies, and cancer. Therapeutic targeting with Jakinibs has revolutionized treatment for several autoimmune diseases.
- Other names
- JAK-STAT signaling pathwayJAK/STAT pathwayJAK STAT pathway
02
Mechanism of action
Small-molecule inhibitors block specific JAK components (JAK1/JAK2/JAK3/TYK2), preventing phosphorylation of STATs and subsequent gene transcription.
03
Biological functions
Signal transductionImmune responseCell growthCell differentiationCell survivalInflammationGene expression regulationApoptosis
04
Disease associations
Autoimmune disordersRheumatoid arthritisPsoriasisPsoriatic arthritisAnkylosing spondylitisHematologic malignanciesMyeloproliferative neoplasmsAtopic eczemaCancerInflammation
05
Safety considerations
Uncontrolled inflammationCancer developmentPersistent activation of downstream genes involved in proliferation/survival pathways
06
Interacting drugs
Jakinibs
1 more in the full profile.
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