Target intelligence / Profile preview

Japanese Encephalitis Virus prM Protein (prM)

Target: prM
Molecular classification: Structural glycoprotein, Viral protein

Overview

The prM protein (precursor membrane protein) of the Japanese encephalitis virus (JEV) is a structural glycoprotein that plays a critical role in viral assembly, maturation, and infectivity. It acts as a chaperone for the envelope E protein, ensuring proper folding and preventing premature fusion activity. Cleavage of prM by furin is essential for the formation of mature, infectious virions. Post-translational modifications, such as N-linked glycosylation, also influence viral biogenesis and pathogenicity.

Mechanism of action

N/A

Biological functions

Virion assemblyChaperone for E protein foldingMembrane associationVirion maturation

Disease associations

InfectionJapanese Encephalitis

Safety considerations

Furin cleavage site mutations can alter pathogenicityGlycosylation site mutations can alter pathogenicity

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