Jasmonate ZIM-domain protein 10 (JAZ10)

Jasmonate ZIM-domain protein 10 (JAZ10) is a key transcriptional repressor in the jasmonate signaling pathway, primarily characterized in plants such as Arabidopsis thaliana. It serves as a negative regulator that prevents the constitutive activation of jasmonate-responsive genes, which are essential for defense against necrotrophic pathogens and herbivores as well as for various developmental processes. JAZ10 functions by physically interacting with transcription factors such as MYC2 and recruiting the co-repressor TOPLESS through the NINJA adapter protein. Upon perception of the bioactive hormone jasmonoyl-isoleucine (JA-Ile), JAZ10 is recognized by the F-box protein CORONATINE INSENSITIVE1 (COI1) and targeted for degradation by the SCF-COI1 E3 ubiquitin ligase complex via the 26S proteasome. Notably, JAZ10 produces alternative splice variants like JAZ10.4 that lack the degradation degron, providing a mechanism for signal desensitization during prolonged stress. While JAZ10 is not a target for human therapeutic intervention, it is a significant target in agricultural biotechnology for optimizing plant resistance and growth-defense trade-offs.

Other names

JAS1Jasmonate-associated 1TIFY9At5g13220TIFY domain-containing protein 9

JAZ10 acts as a transcriptional repressor by binding to MYC transcription factors and recruiting co-repressors like TOPLESS; it undergoes SCF-COI1-mediated ubiquitination and 26S proteasomal degradation upon binding of the bioactive jasmonate hormone JA-Ile to the COI1 receptor.