JC polyomavirus-infected cell

The term "JC polyomavirus-infected cell" refers to any cell that has been infected by the human JC polyomavirus (JCPyV). JCPyV is a non-enveloped DNA virus that infects human cells—predominantly oligodendrocytes and astrocytes in the central nervous system—and can cause progressive multifocal leukoencephalopathy (PML) in immunocompromised individuals[1][3]. The virus attaches via sialylated glycan motifs (e.g., lactoseries tetrasaccharide c, LSTc) and certain cell-surface receptors (e.g., serotonin receptor 5-HT2A) for entry, but infected cells themselves are not molecular targets; rather, they are the consequence of viral infection[1][3]. The phrase does not denote a defined and targetable molecule, receptor, enzyme, or transporter. There is a fundamental issue with this entry: it represents a disease state of a cell and not a molecular drug target. All structured fields are null except for "aliases" and "description," which clarify the usage and meaning of the term[1][2][3][4].

Other names

JC virus-infected cellJCPyV-infected cellJCV-infected cell