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Target intelligence / Profile preview
JC polyomavirus Large T antigen (JC TAg)
- Target
- JC TAg
- Molecular classification
- Viral protein, Oncoprotein, DNA binding protein
01
Overview
The JC polyomavirus Large T antigen (JC TAg) is a multifunctional viral protein crucial for the JCPyV life cycle. It plays a key role in viral DNA replication by binding to the viral origin of replication and recruiting host cell replication machinery. Additionally, JC TAg modulates host cell cycle pathways to create a cellular environment conducive to viral replication. It has oncogenic potential in some contexts. Targeting Large T antigen represents a potential therapeutic strategy for treating PML by disrupting viral replication.
- Other names
- JCPyV Large T antigenJC T antigenJCPyV TAg
02
Mechanism of action
Inhibition of Large T antigen function (e.g., DNA binding, helicase activity) could disrupt viral replication and potentially halt PML progression.
03
Biological functions
Viral replicationHost cell cycle modulationTranscriptional regulation
04
Disease associations
Progressive multifocal leukoencephalopathy (PML)Tumorigenesis (potential)
05
Safety considerations
Off-target effects on host cell cycle regulationPotential for drug resistance developmentDelivery challenges to the CNS
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