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JC polyomavirus peptide-major histocompatibility complex
- Molecular classification
- Other (antigen presentation complex), Major histocompatibility complex class I or II (for the MHC component)
01
Overview
The JC polyomavirus peptide-MHC complex describes the molecular structure in which a peptide derived from the JC polyomavirus (JCV) is bound by an MHC class I or II molecule on host cells, enabling recognition by T cells and facilitating the adaptive immune response. The JC polyomavirus itself is a non-enveloped, double-stranded DNA virus that can cause progressive multifocal leukoencephalopathy in immunocompromised patients[2][3][5]. MHC molecules present viral peptides on the cell surface for surveillance by the immune system[1].
- Other names
- JC polyomavirus antigen-MHC complexJCV peptide-MHC complex
02
Biological functions
Immune response (specifically antigen presentation by MHC molecules)
03
Disease associations
Infection (JC polyomavirus causes progressive multifocal leukoencephalopathy, PML)
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