Josephin domain containing 1 pseudogene

"Josephin domain containing 1 pseudogene" is a genomic sequence similar to the protein-coding Josephin domain containing 1 (JOSD1) gene, but contains mutations or sequence alterations that prevent it from encoding a functional protein[2][4][5]. Pseudogenes can be classified as unitary, duplicated (unprocessed), or processed; most lack coding capacity due to acquired mutations. While some pseudogenes may be transcribed and potentially exert regulatory effects, they are not conventional therapeutic targets. In the mouse genome, similar pseudogene entries are annotated as "Josd1-ps"[5]. The protein-coding JOSD1 gene is a cysteine-type deubiquitinase with roles in protein deubiquitination and cellular membrane processes, but these functional properties do not apply to its pseudogenes[3][1]. Key distinction: This entry refers to a pseudogene (noncoding, usually nonfunctional as a protein), not the protein-coding JOSD1 gene which is relevant for molecular function and therapeutic targeting. If structured molecular data are needed for the Josephin domain-containing cysteine protease, refer to the canonical gene JOSD1 (ENSG00000100221), not the pseudogene ENSG00000270859[3][1].

Other names

Josephin domain containing 1 pseudogeneJOSD1 pseudogeneJosd1-ps