Jumonji domain-containing protein 1C (JMJD1C)

Jumonji domain-containing protein 1C (JMJD1C) is a member of the lysine demethylase 3 (KDM3) family that functions as an epigenetic regulator, removing methyl groups from lysine residues on histone and non-histone proteins. It acts as a transcriptional coactivator for certain nuclear hormone receptors, regulates the DNA damage response through demethylation of the mediator of DNA damage checkpoint 1 (MDC1), and is crucial for maintaining genome integrity[1][4][3]. In addition to its role in transcriptional regulation, JMJD1C is necessary for spermatogenesis and stem cell renewal, and is implicated in the pathogenesis of cancers such as acute myeloid leukemia as well as neurodevelopmental disorders like Rett syndrome and intellectual disability[1][3]. It interacts with key regulators of DNA repair, such as MDC1 and RNF8, facilitating BRCA1-dependent homologous recombination repair pathways[4]. JMJD1C's broad functions in chromatin dynamics, cellular metabolism, and maintenance of cell identity make it a multifaceted target in disease and development[1][2][3][4].

Other names

JHDM2CKIAA1380TRIP8TR-interacting protein 8DKFZp761F0118FLJ14374KDM3CProbable JmjC domain-containing histone demethylation protein 2CThyroid receptor-interacting protein 8putative JmjC domain-containing histone demethylation protein 2CJmjd1C

Inhibition of JMJD1C would be expected to increase methylation of its substrates (including histone and non-histone proteins), potentially altering DNA damage response, gene expression, and cell fate decisions[3][4][1].