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Target intelligence / Profile preview
Jumonji Domain-Containing Protein 2E (JMJD2E)
- Target
- JMJD2E
- Molecular classification
- Enzyme, Histone Modification, JmjC Domain-containing Protein, Histone Demethylase
01
Overview
Jumonji Domain-Containing Protein 2E (JMJD2E), also known as Lysine Demethylase 4E (KDM4E), is a histone demethylase that belongs to the JmjC domain-containing protein family. It catalyzes the demethylation of histone H3 at lysine 9 (H3K9), removing both di-methyl and tri-methyl groups. JMJD2E plays a role in epigenetic regulation, influencing gene expression by modifying chromatin structure. It is involved in processes such as embryonic stem cell pluripotency and differentiation, making it a potential target for therapeutic intervention, particularly in cancer.
- Other names
- KDM4ELysine Demethylase 4E
02
Mechanism of action
Inhibits histone demethylation, specifically H3K9me2 and H3K9me3
03
Biological functions
Epigenetic RegulationChromatin RemodelingGene Expression RegulationRegulation of PluripotencyRegulation of Differentiation
04
Disease associations
CancerOther
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