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Target intelligence / Profile preview
Jumping translocation breakpoint protein (JTB)
- Target
- JTB
- Molecular classification
- Other (Transmembrane orphan receptor, not categorized as GPCR, ion channel, enzyme, etc.)
01
Overview
Jumping translocation breakpoint protein (JTB) is a highly conserved transmembrane orphan receptor encoded by the JTB gene in humans. The biologically relevant protein is involved in mitosis and cytokinesis and may interact with the chromosomal passenger complex (CPC), regulating chromosome alignment and condensation during cell division. It is also implicated in mitochondrial membrane integrity and cell proliferation, with increased expression in some tumors such as prostatic carcinoma. "JTBP1" refers to a pseudogene annotation with no current biological or therapeutic relevance; researchers focus on the protein-coding gene "JTB" for biological studies.
- Other names
- Jumping translocation breakpoint proteinJTBProstate androgen-regulated protein (PAR)
02
Mechanism of action
Not applicable; no known drugs act directly on JTB or its pseudogenes.
03
Biological functions
Regulation of mitosis and cytokinesisRegulation of cell proliferationComponent of chromosomal passenger complex (CPC)Inhibition of apoptosisMitochondrial membrane integrity (overexpression may cause swelling and reduce membrane potential)
04
Disease associations
Cancer (implicated in prostatic carcinomas and possibly other tumor types)
05
Safety considerations
None documented, as JTBP1 is a pseudogene and JTB is not a drug target. Overexpression of JTB can affect mitochondrial function and apoptosis, which may be relevant in research but not therapeutic contexts
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