Junctional adhesion molecule C (JAM3)

Junctional adhesion molecule C (JAM3) is a 310-amino acid transmembrane glycoprotein (molecular weight ~35 kDa), belonging to the immunoglobulin superfamily adhesion molecules[6][3][2]. JAM3 contains two extracellular immunoglobulin-like domains, a single transmembrane segment, and a cytoplasmic tail with phosphorylation sites and a PDZ-binding motif[2][4]. It is primarily localized at tight junctions of endothelial and epithelial cells, where it regulates cell–cell adhesion, polarization, and barrier function[5][1][6]. JAM3 uniquely contributes to hematopoietic stem cell homing, vascular permeability, angiogenesis, and leukocyte–platelet adhesion during inflammation by interacting with integrin Mac-1 and other JAM family members[2][8][3]. Clinically, JAM3 mutations are associated with hemorrhagic destruction of the brain and congenital cataracts in rare syndromes[6]. Dysregulation of JAM3 is implicated in vascular disease, inflammation, and cancer progression[4][8].

Other names

JAM3JAM-CJunctional adhesion molecule 3Junctional adhesion molecule CJAMCJAM-3sJAM-CSoluble JAM-CUNQ859/PRO1868