Junctional cadherin 5-associated protein (JCAD)

Junctional cadherin 5-associated protein (JCAD) is an endothelial cell–cell junction protein, localized specifically at cell–cell junctions in endothelial cells where it interacts with VE-cadherin. JCAD is encoded by the KIAA1462 gene. Naturally occurring mutations or SNPs in KIAA1462/JCAD have been associated with increased risk of coronary artery disease, late-onset Alzheimer disease, and the distribution of emphysema. Although important in maintaining vascular integrity and endothelial function, JCAD does not have known domains with established molecular function and is not currently considered a direct target of any approved pharmacological therapies[1][3][5][4][6].

Other names

KIAA1462junctional protein associated with coronary artery diseaseJCAD proteinJCAD_HUMAN