Jupiter microtubule-associated homolog 2 (JPT2)

Jupiter microtubule-associated homolog 2 (JPT2) is a highly conserved, widely expressed human protein encoded by the JPT2 gene, also known as HN1L and several other aliases. Functionally, it is an accessory protein that binds nicotinic acid adenine dinucleotide phosphate (NAADP) with nanomolar affinity and is essential for NAADP-evoked intracellular calcium release via two-pore channels (TPCs) and ryanodine receptors. JPT2 mediates endolysosomal trafficking events, T-cell activation, cell proliferation, and is required for entry of coronaviral particles such as SARS-CoV-2 through endolysosomal pathways. Overexpression of JPT2 stimulates tumor growth and metastasis in various cancers, while knockdown suppresses cell growth and migration. JPT2 is emerging as a significant therapeutic target in cancer, immune regulation, and viral infection

Other names

JPT2C16orf34HN1LHematological and neurological expressed 1-likeL11FLJ13092KIAA1426CRAMP_1-like

Drugs or inhibitors that modulate NAADP-mediated Ca^2+ signaling, two-pore channel antagonists affecting viral entry or trafficking (inferred from TPC literature, not specific to JPT2). Future therapeutics may target JPT2 to block NAADP sensitivity, or intracellular Ca^2+ mobilization in related disease states.