Methoprene-tolerant receptor (Met)

The **Methoprene-tolerant receptor** (Met) is the canonical intracellular **juvenile hormone receptor** in insects, classified as a basic helix-loop-helix (bHLH) Per-Arnt-Sim (PAS) domain transcription factor[2][4][10]. Met directly and specifically binds juvenile hormone III and its synthetic mimics such as methoprene and pyriproxyfen through its PAS-B domain. Upon ligand binding, Met interacts with its dimerization partner Taiman (Tai) to form a receptor complex that translocates to the nucleus, where it regulates gene expression needed for larval development, prevention of metamorphosis, reproduction, and certain behaviors[2][4][10]. Met/juvenile hormone signaling is targeted by several insect growth regulator (IGR) pesticides used in vector and pest control. The receptor is exclusive to insects and plays no direct role in vertebrate diseases but is of broad importance for entomology and pest management. **Note:** - While some recent studies have identified potential membrane receptors for JH (such as RTKs CAD96CA and FGFR1 in Helicoverpa armigera)[1], the overwhelmingly accepted and canonical receptor referred to by "juvenile hormone receptor" is Methoprene-tolerant (Met), an intracellular transcription factor[2][4][10]. Use of "juvenile hormone receptor" without qualifier is generally mapped to Met in the scientific and applied entomological literature. - No significant issues with nomenclature or target identity in the current query. **References:** Information synthesized from sources[1][2][4][10] for molecular identity, function, and pharmacology. Contextual details for function and drug interaction from [3][6][7].

Other names

Methoprene-tolerant proteinMetJuvenile hormone receptorJHRJH receptor

Agonists (e.g., methoprene, pyriproxyfen) bind the C-terminal PAS-B domain of Met, activating juvenile hormone signaling and mimicking the endogenous ligand to block metamorphosis