Juvenile hormone receptor (Methoprene-tolerant) (Met)

The Juvenile hormone receptor, primarily identified as the Methoprene-tolerant (Met) protein, is a central regulator of insect development, metamorphosis, and reproduction (Jindra et al., 2013, Annual Review of Entomology). As a member of the basic helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) family of transcription factors, Met serves as the primary transducer of juvenile hormone (JH) signaling (Li et al., 2011, PNAS). Upon binding JH, Met forms a heterodimeric complex with the co-activator Taiman (Tai), which then binds to specific DNA sequences known as JH response elements to activate target genes like Krüppel homolog 1 (Kr-h1) (Charles et al., 2011, PNAS). This molecular pathway is essential for maintaining the insect in a juvenile state and preventing premature metamorphosis into the adult form. While the receptor is not present in vertebrates, it is a major target for insect growth regulators (IGRs) such as methoprene and pyriproxyfen, which act as JH mimics (PubChem). These compounds disrupt the endocrine balance of pests and disease vectors, leading to developmental failure or sterility, making the receptor a critical focus for agricultural pest management and the control of insect-borne diseases like malaria.

Other names

Methoprene-tolerant proteinJH receptorJHRbHLH-PAS transcription factor Met

Binding and activation of the Methoprene-tolerant (Met) protein to mimic natural juvenile hormone, thereby disrupting developmental transitions and reproductive cycles in insects.