Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
K(lysine) acetyltransferase 6A (KAT6A)
- Target
- KAT6A
- Molecular classification
- Enzyme, Histone modification, Transcription factor, Histone Acetyltransferases: MOZ/YBFR2/SAS2/TIP60 family
01
Overview
K(lysine) acetyltransferase 6A (KAT6A) is a histone acetyltransferase that plays a critical role in chromatin remodeling and gene regulation. As a member of the MOZ/YBFR2/SAS2/TIP60 family, KAT6A acetylates lysine residues on histones, particularly H3K9 and H3K23, influencing chromatin accessibility and transcription. It is essential for hematopoietic stem cell development and acts as a global activator of HOX genes, impacting body segment identity during development. Mutations in KAT6A are associated with Arboleda-Tham syndrome, a neurodevelopmental disorder. KAT6A is also implicated in cancer progression, particularly in AML and breast cancer, making it a potential diagnostic and therapeutic target.
- Other names
- MOZMYST3ZNF220
02
Mechanism of action
Inhibition of histone acetyltransferase activity (potential)
03
Biological functions
Chromatin remodelingRegulation of gene expressionHistone lysine acetylation (H3/H4/p53)Hematopoietic stem cell maintenance/developmentGlobal activator of HOX genes
04
Disease associations
Arboleda-Tham syndromeCancerAcute myeloid leukemiaInvasive ductal breast carcinomaNeurodevelopmental disorders
05
Safety considerations
Potential for off-target effects due to broad histone modification activityDisruption of normal developmental processes
06
Biomarkers
KAT6A expression levels in breast cancerKAT6A rearrangements/mutations in AML
Beyond the preview
Go deeper on K(lysine) acetyltransferase 6A (KAT6A).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on K(lysine) acetyltransferase 6A (KAT6A).