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Kainate Glutamate Receptor (KAR)
- Target
- KAR
- Molecular classification
- Ionotropic glutamate receptor, Ligand-gated ion channel
01
Overview
The kainate glutamate receptor (KAR) is an ionotropic glutamate receptor that mediates fast synaptic transmission and modulates neuronal excitability in the CNS. It is a tetrameric complex assembled from GluK1-GluK5 subunits, forming homo- or heteromers. KARs are widely expressed throughout the brain and play roles in modulating neurotransmitter release, regulating neuronal excitability, and synaptic development. Due to their modulatory roles in neurotransmission, KARs are considered potential targets for pharmacotherapy in neurological diseases such as epilepsy or disorders involving basal ganglia dysfunctions.
- Other names
- Kainite ReceptorGluK1GluK2GluK3GluK4GluK5GluR5GluR6GluR7KA1KA2
02
Mechanism of action
Ligand-gated ion channel activation/inhibition
03
Biological functions
Modulation of neurotransmitter releaseRegulation of neuronal excitabilitySynaptic developmentModulation of synaptic transmission
04
Disease associations
EpilepsyNeurological disordersBasal ganglia dysfunctions
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