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Target intelligence / Profile preview
Kainate Ion Channel (KAR)
- Target
- KAR
- Molecular classification
- Ion channel, Ligand-gated ion channel, Glutamate receptor, Ionotropic glutamate receptor
01
Overview
Kainate receptors are a subclass of ionotropic glutamate receptors that function as tetrameric ligand-gated ion channels. They mediate excitatory neurotransmission in the central nervous system by allowing the flow of ions across neuronal membranes upon activation by glutamate or kainic acid. These receptors play key roles in modulating neuronal circuits, synaptic plasticity, and are implicated in several neurological and psychiatric disorders including epilepsy, depression, schizophrenia, anxiety, and autism.
- Other names
- Kainate ReceptorKainic Acid ReceptorGluK1GluK2GluK3GluK4GluK5GRIK1GRIK2GRIK3GRIK4GRIK5
02
Mechanism of action
Agonist-induced ion channel opening; Allosteric modulation of channel gating
03
Biological functions
Excitatory neurotransmissionModulation of synaptic plasticityRegulation of neurotransmitter releaseIon transport
04
Disease associations
EpilepsyDepressionSchizophreniaAnxietyAutismHuntington's diseaseBipolar disorder
05
Safety considerations
Potential for excitotoxicityImplication in neurological and psychiatric disorders
06
Interacting drugs
L-glutamate
3 more in the full profile.
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