Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Kainate-Type Glutamate Receptor (KAR)
- Target
- KAR
- Molecular classification
- Ionotropic glutamate receptor, Ligand-gated ion channel, Receptor
01
Overview
Kainate-type glutamate receptors (KARs) are a subfamily of ionotropic glutamate receptors that mediate fast excitatory synaptic transmission and modulate neuronal circuitry. They are tetrameric complexes formed from GluK1-GluK5 subunits, acting as ligand-gated ion channels that regulate neurotransmitter release and neuronal excitability. KARs are implicated in various neurological disorders, including epilepsy, schizophrenia, and neurodegenerative diseases, making them potential therapeutic targets.
- Other names
- Kainate ReceptorGluK1 ReceptorGluK2 ReceptorGluK3 ReceptorGluK4 ReceptorGluK5 ReceptorGluR5 ReceptorGluR6 ReceptorGluR7 ReceptorKA1 ReceptorKA2 Receptor
02
Mechanism of action
Agonist binding opens ion channel, allowing ion flow and modulating neuronal excitability; antagonists block agonist binding and prevent channel opening.
03
Biological functions
Synaptic transmissionNeuronal excitability modulationNeurotransmitter release regulationSynaptic plasticity
04
Disease associations
Epilepsy/seizuresSchizophreniaDepressionStrokeAlzheimer’s diseaseParkinson’s diseaseNeurodegenerative diseasePsychiatric disorders
05
Safety considerations
Off-target effects on other iGluRs (AMPA, NMDA)Limited subtype selectivity of current ligandsPotential for excitotoxicity
06
Interacting drugs
Kainic acid
4 more in the full profile.
Beyond the preview
Go deeper on Kainate-Type Glutamate Receptor (KAR).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Kainate-Type Glutamate Receptor (KAR).