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Target intelligence / Profile preview
Kainate-type glutamate receptor subunit GRIK3 (GRIK3)
- Target
- GRIK3
- Molecular classification
- Ligand-gated ion channel, Ionotropic glutamate receptor, Kainate receptor
01
Overview
GRIK3 is a subunit of the kainate receptor family of ionotropic glutamate receptors. It functions as an excitatory neurotransmitter receptor, mediating fast synaptic transmission in the central nervous system upon binding of L-glutamate or agonists like kainic acid. GRIK3 plays roles in synaptic potentiation and modulates synaptic plasticity. Overexpression has been linked to increased proliferation/migration of breast cancer cells.
- Other names
- Glutamate Receptor Ionotropic, Kainate 3
02
Mechanism of action
Agonist binding leads to channel opening and cation influx
03
Biological functions
Excitatory neurotransmissionSynaptic potentiationModulation of synaptic plasticityCation influx
04
Disease associations
Neurodegenerative diseaseCancer
05
Interacting drugs
L-glutamate
2 more in the full profile.
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