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Target intelligence / Profile preview
Kainate-type Ionotropic Glutamate Receptor (KAR)
- Target
- KAR
- Molecular classification
- Ion channel, Ligand-gated ion channel, Glutamate receptor, Ionotropic glutamate receptor
01
Overview
Kainate-type ionotropic glutamate receptors (KARs) are a subfamily of the ionotropic glutamate receptor (iGluR) family, which mediate fast excitatory neurotransmission in the mammalian central nervous system. KARs function as ligand-gated ion channels that respond to the neurotransmitter L-glutamate and play key roles in both pre- and postsynaptic modulation of neuronal circuits. KARs are tetrameric complexes assembled from five possible subunits: GluK1, GluK2, GluK3, GluK4, and GluK5. Dysfunction or altered expression/activity is implicated in several neurological disorders including epilepsy, schizophrenia, depression, stroke recovery deficits, Alzheimer’s disease progression, among others.
- Other names
- Kainate receptorGluK1 receptorGluK2 receptorGluK3 receptorGluK4 receptorGluK5 receptorGluR5 receptorGluR6 receptorGluR7 receptorKA1 receptorKA2 receptor
02
Mechanism of action
Ligand-gated ion channel activation/inhibition
03
Biological functions
NeurotransmissionSynaptic transmissionSynaptic plasticityRegulation of neuronal excitabilityModulation of neurotransmitter releaseLearningMemoryNeuronal circuit development
04
Disease associations
EpilepsySchizophreniaDepressionStrokeAlzheimer's disease
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