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Target intelligence / Profile preview
Glutamate receptor ionotropic kainate type (Kainate receptor (KAR))
- Target
- Kainate receptor (KAR)
- Molecular classification
- Ion channel, Receptor
01
Overview
Kainate receptors are ionotropic glutamate receptors that play a role in excitatory and inhibitory neurotransmission. They are composed of five subunits (GluK1-5) and are involved in synaptic plasticity and various neurological functions. Kainate receptors are less understood than other glutamate receptors like AMPA and NMDA but are important for modulating neuronal circuitry.
- Other names
- Kainic acid receptorIonotropic glutamate receptor kainate type
02
Mechanism of action
Modulation of excitatory and inhibitory neurotransmission, regulation of synaptic plasticity
03
Biological functions
Signal transductionExcitatory neurotransmissionInhibitory neurotransmissionSynaptic plasticity
04
Disease associations
Neurodegenerative diseaseEpilepsyOther neurological disorders
05
Safety considerations
Potential for excitotoxicitytherapeutic challenges in targeting specific subunits
06
Interacting drugs
Kainic acid (agonist)
2 more in the full profile.
07
Biomarkers
Not specifically identified for kainate receptors alone
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