Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Kallikrein-14 (KLK14)
- Target
- KLK14
- Molecular classification
- Serine protease, Kallikrein subfamily, Enzyme
01
Overview
Kallikrein-14 (KLK14) is a serine protease belonging to the kallikrein subfamily. It exhibits both trypsin-like and chymotrypsin-like activity and is involved in various biological processes, including blood pressure regulation, epidermal desquamation, and potentially cancer progression. It is expressed in multiple tissues including breast, skin, prostate, and brain. KLK14 is implicated in prostate, breast, and ovarian cancers and may serve as a biomarker.
- Other names
- KLK-L6kallikrein related peptidase 14Gk14mGK14
02
Mechanism of action
Serine-type endopeptidase; cleaves peptide bonds
03
Biological functions
Regulation of blood pressureEpidermal desquamationProteolytic cascadesSemen liquefactionStratum corneum degradationTumor growthInvasionAngiogenesis
04
Disease associations
CancerProstate cancerBreast cancerOvarian cancer
05
Safety considerations
Potential for off-target effects due to broad substrate specificityDysregulation may contribute to tumor progressionInhibition of KLK14 could disrupt normal physiological processes like epidermal desquamation
06
Interacting drugs
Macroglobulins
6 more in the full profile.
07
Biomarkers
KLK14 expression in prostate cancerKLK14 expression in breast cancerKLK14 expression in ovarian cancer
Beyond the preview
Go deeper on Kallikrein-14 (KLK14).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Kallikrein-14 (KLK14).