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Kallikrein B1 (KLKB1)
- Target
- KLKB1
- Molecular classification
- Serine protease, Enzyme
01
Overview
Kallikrein B1 (KLKB1) is a serine protease that circulates in the blood as prekallikrein. Upon activation by factor XIIa, it becomes plasma kallikrein, playing key roles in blood coagulation, fibrinolysis, kinin generation (producing bradykinin), and inflammation. It participates in the intrinsic coagulation pathway and the kallikrein-kinin system (KKS). Deficiency of functional plasma kallikrein, due to mutations in KLKB1, leads to prekallikrein deficiency, typically asymptomatic.
- Other names
- PrekallikreinPlasma KallikreinFletcher factor
02
Mechanism of action
Serine protease inhibitor (potential)
03
Biological functions
Blood coagulationFibrinolysisKinin generationBradykinin productionInflammation
04
Disease associations
InflammationCardiovascular diseasePrekallikrein deficiency
05
Safety considerations
Potential bleeding risk if inhibited excessively
06
Biomarkers
aPTT (activated partial thromboplastin time)
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