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Target intelligence / Profile preview
Kallikrein-related Peptidase 14
- Molecular classification
- Enzyme, Serine protease
01
Overview
Kallikrein-related peptidase 14 (KLK14) is a serine protease involved in tissue remodeling, skin homeostasis, and cancer progression. It is produced as an inactive zymogen and activated by proteolytic cleavage. KLK14 participates in skin desquamation and is implicated in inflammatory skin diseases. It is overexpressed in prostate cancer and is associated with aggressive features and metastasis. It modulates signaling pathways relevant to cancer progression, including the MAP kinase and Interleukin-1 receptor pathways. KLK14 regulates genes involved in tumor biology and cellular migration/invasion. It is considered a potential therapeutic target and biomarker for cancer aggressiveness and treatment response.
- Other names
- KLK14KLK-L6Kallikrein related peptidase 14
02
Mechanism of action
Inhibition of serine protease activity of KLK14
03
Biological functions
Tissue remodelingSkin homeostasisSkin desquamationCell adhesionCell migration
04
Disease associations
CancerProstate CancerSkin DisordersInflammatory skin diseasesNetherton syndrome
05
Safety considerations
Potential for off-target effects due to similarity with other kallikreinsDysregulation can lead to inflammatory skin diseases
06
Biomarkers
Prostate cancer aggressivenessTreatment response in prostate cancer
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