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Target intelligence / Profile preview
Kallikrein-related Peptidase 3 (PSA)
- Target
- PSA
- Molecular classification
- Enzyme, Serine endopeptidase
01
Overview
Kallikrein-related peptidase 3 (KLK3), also known as prostate-specific antigen (PSA), is a serine protease enzyme secreted by the prostate gland. It plays a crucial role in semen liquefaction and is widely used as a biomarker for prostate cancer and other prostatic diseases. KLK3 is also implicated in various biological processes, including cell growth regulation, apoptosis, and immune response modulation, and is an attractive therapeutic target.
- Other names
- Prostate-specific antigengamma-seminoproteinsemenogelaseP-30 antigenseminin
02
Mechanism of action
Inhibition of KLK3 enzymatic activity
03
Biological functions
Semen liquefactionRegulation of cell growthApoptosisAngiogenesis inhibitionImmune response modulationCell proliferationTumor suppressionTumor promotion
04
Disease associations
Prostate cancerProstatitisBenign prostatic hyperplasiaOvarian cancer
05
Safety considerations
Potential for off-target effectsDrug resistance
06
Biomarkers
Prostate cancer detectionProstate cancer monitoringProstatic diseases assessment
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