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Target intelligence / Profile preview
Kallikrein-related peptidase 4 (KLK4)
- Target
- KLK4
- Molecular classification
- Enzyme, Serine Protease, Kallikrein Family
01
Overview
Kallikrein-related peptidase 4 (KLK4) is a serine protease enzyme involved in enamel formation during tooth development. It is also implicated in cancer progression and endometriosis. KLK4 facilitates the degradation and removal of enamel matrix proteins. Aberrant expression is observed in certain cancers and may promote proliferation and invasion. It is considered a potential therapeutic target, and its expression patterns can serve as a biomarker for certain cancers.
- Other names
- AI2A1ARM1EMSPEMSP1PRSS17PSTSKLK-L1
02
Mechanism of action
Serine-type endopeptidase; target for inhibitors
03
Biological functions
Enamel protein degradationTissue remodelingProteolysisCollagen chain trimerizationUrokinase-type plasminogen activator/uPAR-mediated signaling
04
Disease associations
Amelogenesis ImperfectaCancerEndometriosisTumorigenesis
05
Safety considerations
Off-target effects due to serine protease family similarityPotential for dysregulation of protease activity
06
Biomarkers
Prostate cancerBreast cancer
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