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Target intelligence / Profile preview
Kallikrein-related peptidase 5 (KLK5)
- Target
- KLK5
- Molecular classification
- Serine protease, Kallikrein-related peptidase
01
Overview
Kallikrein-related peptidase 5 (KLK5) is a serine protease primarily expressed in the epidermis and plays a crucial role in skin barrier formation and desquamation. It processes profilaggrin to filaggrin, an essential protein for epidermal differentiation and barrier integrity. KLK5 can activate other kallikreins, initiating a proteolytic cascade important for tissue homeostasis and repair. Dysregulation of KLK5 is associated with skin diseases like Netherton syndrome and has potential as a biomarker for ovarian cancer.
- Other names
- Stratum corneum tryptic enzymeSCTEKLKL2KLK-L2
02
Mechanism of action
Proteolytic cleavage of proteins involved in skin barrier function and desquamation; activation of other kallikreins
03
Biological functions
Skin barrier formationDesquamationExtracellular matrix remodelingProfilaggrin processing
04
Disease associations
Netherton syndromeOvarian cancerDermatological conditions (related to epidermal homeostasis)
05
Safety considerations
Abnormal regulation can lead to skin diseasesPotential for off-target effects due to protease activity
06
Biomarkers
Ovarian cancer biomarker
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