Target intelligence / Profile preview

Kallikrein Related Peptidase 7 (KLK7)

Target: KLK7
Molecular classification: Enzyme, Serine protease, Kallikrein

Overview

Kallikrein-related peptidase 7 (KLK7) is a serine protease involved in skin desquamation by cleaving proteins within corneodesmosomes. It plays roles in skin homeostasis, and its dysregulation is implicated in skin disorders like atopic dermatitis. Overexpression is observed in pancreatic cancer, promoting tumor progression, while in the brain, it can degrade amyloid-beta peptides, offering potential therapeutic avenues in Alzheimer's disease. Inhibitors are being developed, targeting its enzymatic activity to treat various pathological conditions.

Other names: SCCEStratum Corneum Chymotryptic Enzyme

Mechanism of action

Inhibition of KLK7 enzymatic activity by binding to the active site; Modulation of KLK7 expression via glutamatergic signaling pathways (e.g., by memantine)

Biological functions

Skin desquamationExtracellular matrix remodelingProteolytic cascadeAmyloid-beta degradation (in astrocytes)

Disease associations

Atopic dermatitisPancreatic cancerAlzheimer’s diseaseSkin disorders

Safety considerations

Potential for off-target effects due to similarity to other serine proteasesDysregulation of skin barrier function with excessive inhibitionUnknown long-term effects of systemic KLK7 inhibition

Interacting drugs

Coumarinic esters

1 more in the full profile.

Biomarkers

KLK7 expression levels in skinKLK7 expression levels in pancreatic cancer tissue

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