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KANSL1 antisense RNA 1 (KANSL1-AS1)
- Target
- KANSL1-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA, Non-protein coding RNA, Other
01
Overview
KANSL1 antisense RNA 1 (KANSL1-AS1) is a long non-coding RNA located on chromosome 17q21.31, transcribed antisense to the KANSL1 gene. Unlike protein-coding genes, KANSL1-AS1 does not encode a protein but is believed to regulate the expression of nearby or overlapping genes, including the KANSL1 gene that has a key role in chromatin modification and gene expression. Its function may include modulation of epigenetic states, acting through chromatin remodeling or other mechanisms of RNA-mediated regulation. KANSL1-AS1 is upregulated in certain cancers and has been reported as a prognostic marker in osteosarcoma, where its abnormal expression is significantly associated with disease progression and outcome. However, it is not classified as a direct therapeutic target such as a receptor, enzyme, or transporter, and no drugs are known to modulate KANSL1-AS1 specifically.
- Other names
- KANSL1 antisense RNA 1 (non-protein coding)lnc-KANSL1-1ENSG00000214401
02
Biological functions
Regulation of gene expressionModulation of epigenetic states, possibly via interaction with chromatin and transcriptional regulation
03
Disease associations
Cancer (aberrant expression linked to prognosis in various tumors, including osteosarcoma (OS))Potential roles in neurodevelopmental disorders, through regulatory effects on the KANSL1 gene
04
Biomarkers
Prognostic marker for osteosarcoma and potentially other cancers, based on expression level correlations with progression and prognosis
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