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Target intelligence / Profile preview
Kappa Myeloma Antigen (KMA)
- Target
- KMA
- Molecular classification
- Tumor-associated antigen, Epitope, Kappa light chain
01
Overview
Kappa Myeloma Antigen (KMA) is a tumor-associated antigen found on the surface of malignant plasma cells, particularly in patients with kappa-type multiple myeloma. It is an epitope associated with free kappa light chains that are inserted into the membrane of malignant plasma cells. KMA serves as a target for monoclonal antibody and CAR-T cell-based immunotherapies.
02
Mechanism of action
Antibody-dependent cell-mediated cytotoxicity (ADCC), T-cell mediated cytotoxicity
03
Biological functions
Cell surface markerAntigen presentationTumor cell recognition
04
Disease associations
Multiple myelomaPlasma cell dyscrasiasPlasmacytomaLymphoplasmacytoid disordersAL Amyloidosis
05
Safety considerations
On-target, off-tumor toxicity (potential)Cytokine release syndrome (CRS)Neurotoxicity
06
Interacting drugs
Kappamab
1 more in the full profile.
07
Biomarkers
KMA expression on plasma cells
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