Karyopherin alpha pseudogene

The karyopherin alpha pseudogene (ENSG00000251419, LOC391798) is a genomic DNA segment that is structurally similar to functional karyopherin alpha protein-coding genes but contains mutations and/or deletions that prevent it from producing a functional protein. Pseudogenes are typically considered nonfunctional remnants of gene duplication or retrotransposition events, lacking protein-coding capacity and generally not involved in direct therapeutic targeting. However, recent research shows that some pseudogenes can be transcribed as non-coding RNAs, potentially playing roles in gene regulation by acting as decoys for microRNAs, antisense transcripts, or competitive endogenous RNAs. For most pseudogenes, including this locus, there is no well-established functional or druggable activity.

Other names

LOC391798ENSG00000251419karyopherin alpha pseudogene