KAT8 regulatory NSL complex subunit 1 (KANSL1)

KAT8 regulatory NSL complex subunit 1 (KANSL1) is a nuclear protein that functions as a core scaffolding component of the evolutionarily conserved nonspecific lethal (NSL) complex, a multiprotein assembly crucial for chromatin-based transcriptional regulation and cell division[3][5][8]. The NSL complex, which includes the histone acetyltransferase MOF (KAT8), is responsible for acetylating lysine residues (notably Lys-16 and Lys-5) on histone H4, promoting transcriptionally active chromatin and the priming of developmental genes[1][4]. KANSL1 is predicted to be intrinsically disordered and mediates interactions among NSL complex subunits, playing a central role as a scaffold to recruit and organize the complex on chromatin targets[5][9]. During mitosis, KANSL1 relocates to the mitotic spindle, stabilizing microtubule minus ends and ensuring proper chromosome segregation[1][3]. Loss of function or deletion of KANSL1 causes Koolen-de Vries syndrome, characterized by developmental delay, intellectual disability, congenital organ anomalies, and distinctive facial features[2][7]. Although alterations in its expression and function are linked to disease states, KANSL1 itself is not a direct drug target, nor are there presently drugs or small molecule modulators specifically interacting with it.

Other names

CENP-36KIAA1267MSL1V1NSL1hMSL1v1DKFZP727C091MSL1v1KDVSMLL1/MLL complex subunit KANSL1MSL1 homolog 1NSL complex protein NSL1Non-specific lethal 1 homologcentromere protein 36C17DELq21.31DEL17Q21.31